Rapid symptom reduction within hours, not weeks.
Spravato Esketamine
Leading Esketamine Therapy For Depression Columbus, OH
Spravato is a nasal spray medication used for mental health treatment. It contains the chemical compound: esketamine. This well-researched type of therapy can relieve patients’ difficult-to-treat depressive symptoms.
Spravato Esketamine
Leading Esketamine Therapy For Depression Columbus, OH
Spravato is a nasal spray medication used for mental health treatment. It contains the chemical compound: esketamine. This well-researched type of therapy can relieve patients’ difficult-to-treat depressive symptoms.
Spravato Esketamine
Leading Esketamine Therapy For Depression Columbus, OH
Spravato is a nasal spray medication used for mental health treatment. It contains the chemical compound: esketamine. This well-researched type of therapy can relieve patients’ difficult-to-treat depressive symptoms.
Benefits of Spravato Esketamine
Reduced risk of relapse with continued therapy
FDA-approved for treatment-resistant depression
Benefits of Spravato Esketamine
Rapid symptom reduction within hours, not weeks
Reduced risk of relapse with continued therapy
FDA-approved for treatment-resistant depression
Benefits of Spravato Esketamine
Rapid symptom reduction within hours, not weeks.
Reduced risk of relapse with continued therapy
FDA-approved for treatment-resistant depression
What Is Esketamine?
Esketamine is a derivative of the drug ketamine, which is used medically as an anesthetic. More recently, research has demonstrated success in treating depression with ketamine. This drug is limited to intravenous delivery, which may not be preferable for all patients.
Esketamine demonstrates similar results in reducing depressive symptoms. Unlike ketamine, esketamine can be absorbed by the nasal mucosa, allowing it to be administered via a nasal spray (ie. Spravato). Intravenous esketamine therapy is still possible but is not offered at our clinic.
Why Esketamine for Depression
How it works:
Esketamine operates via a different neural system than typical antidepressants. It alters activity in a particular neurotransmitter system; glutamate. This results in a greater availability of glutamate in the brain and overall elevated levels of brain activity. Greater stimulation in the brain in this way can reduce regulate depressive symptoms (eg. low mood).
Benefits:
In a group of adults with treatment-resistant depression, a greater reduction in depressive symptoms was observed in those who took Spravato and an oral antidepressant (compared to a group who received a placebo in place of Spravato therapy). This outcome was observed at 4 weeks.
In a long-term study, patients who continued their Spravato treatment were less likely to experience a return of depressive symptoms, compared to patients who discontinued therapy. This was recorded at 16 weeks after Spravato therapy.
Short-term and long-term evidence:
Esketamine’s unique mechanism makes it a great option for those who have had difficulties seeing results with prior treatment. Up to 33% of people have low response rates to conventional antidepressants. Clinical trials have shown that esketamine is able to reduce depressive symptoms in most of these individuals.
Compared to conventional antidepressants, which may require weeks to take effect, Spravato therapy provides rapid relief of depressive symptoms within hours of administration.
Are There Side Effects of Spravato?
In 2019, Spravato received FDA approval as medication for treatment-resistant depression (no observed reduction in depressive symptoms after trialing at least 2 types of medication) when used in conjunction with an oral antidepressant. However like many forms of mental health treatment, there is a risk of side effects involved.
The most common side effects include:
Changes in mood (eg. happy, anxious)
Physical reactions (eg. bladder problems, changes in blood pressure, nausea)
Dissociation from thoughts and feelings
Sleepiness or lack of energy
Dizziness
If side effects occur, they generally present 40 minutes after Spravato administration and subside after approximately 2 to 4 hours. Short-term and long-term studies found that less than 7% of patients cease Spravato therapy due to the occurrence of side effects.
What to Expect
Spravato therapy involves a strict dosage and treatment schedule to ensure safe, effective delivery of esketamine for optimal results.
After your session:
- Your healthcare provider will monitor you for 2 hours after your session to confirm when you are ready to go home.
- You will be unable to drive, so you are welcome to bring a support person who can drive you home. However, only patients will be allowed in the treatment and observation room.

- You may not return to work until after a restful sleep.
Your Next Steps
If you are experiencing difficulties treating depressive symptoms and are seeking an effective, novel treatment, book a consultation with us today!
To reach out, call 614-933-4200 or visit our
contact page. When coming into your first appointment, please fill out the form at the end of our
consultation booklet and bring this with you! Here, we will evaluate whether Spravato therapy is suitable for you and work together to discuss your therapy options.
Payment Options
At Optimum TMS and Wellness Suites, we strive to make mental health care accessible to as many people as possible. In addition to cash and credit card payments, we also work with CareCredit to provide greater flexibility in obtaining your mental health treatment. We accept most private and public health insurance policies, including Medicare and Medicaid.
Reach out soon! Our team of board-certified psychiatrists, psychiatric nurse practitioners, and compassionate administration members are dedicated to providing accessible, patient-centered care and want to ensure your comfort in proceeding with any treatment.
What Is Esketamine?
Esketamine is a derivative of the drug ketamine, which is used medically as an anesthetic. More recently, research has demonstrated success in treating depression with ketamine. This drug is limited to intravenous delivery, which may not be preferable for all patients.
Esketamine demonstrates similar results in reducing depressive symptoms. Unlike ketamine, esketamine can be absorbed by the nasal mucosa, allowing it to be administered via a nasal spray (ie. Spravato). Intravenous esketamine therapy is still possible but is not offered at our clinic.
Why Esketamine for Depression
How it works:
Esketamine operates via a different neural system than typical antidepressants. It alters activity in a particular neurotransmitter system; glutamate. This results in a greater availability of glutamate in the brain and overall elevated levels of brain activity. Greater stimulation in the brain in this way can reduce regulate depressive symptoms (eg. low mood).
Benefits:
In a group of adults with treatment-resistant depression, a greater reduction in depressive symptoms was observed in those who took Spravato and an oral antidepressant (compared to a group who received a placebo in place of Spravato therapy). This outcome was observed at 4 weeks.
In a long-term study, patients who continued their Spravato treatment were less likely to experience a return of depressive symptoms, compared to patients who discontinued therapy. This was recorded at 16 weeks after Spravato therapy.
Short-term and long-term evidence:
Esketamine’s unique mechanism makes it a great option for those who have had difficulties seeing results with prior treatment. Up to 33% of people have low response rates to conventional antidepressants. Clinical trials have shown that esketamine is able to reduce depressive symptoms in most of these individuals.
Compared to conventional antidepressants, which may require weeks to take effect, Spravato therapy provides rapid relief of depressive symptoms within hours of administration.
Are There Side Effects of Spravato?
In 2019, Spravato received FDA approval as medication for treatment-resistant depression (no observed reduction in depressive symptoms after trialing at least 2 types of medication) when used in conjunction with an oral antidepressant. However like many forms of mental health treatment, there is a risk of side effects involved.
The most common side effects include:
Changes in mood (eg. happy, anxious)
Physical reactions (eg. bladder problems, changes in blood pressure, nausea)
Dissociation from thoughts and feelings
Sleepiness or lack of energy
Dizziness
If side effects occur, they generally present 40 minutes after Spravato administration and subside after approximately 2 to 4 hours. Short-term and long-term studies found that less than 7% of patients cease Spravato therapy due to the occurrence of side effects.
What to Expect
Spravato therapy involves a strict dosage and treatment schedule to ensure safe, effective delivery of esketamine for optimal results.
After your session:
- Your healthcare provider will monitor you for 2 hours after your session to confirm when you are ready to go home.
- You will be unable to drive, so you are welcome to bring a support person who can drive you home. However, only patients will be allowed in the treatment and observation room.
- You may not return to work until after a restful sleep.
Your Next Steps
If you are experiencing difficulties treating depressive symptoms and are seeking an effective, novel treatment, book a consultation with us today!
To reach out, call
614-933-4200
or visit our
contact page. When coming into your first appointment, please fill out the form at the end of our
consultation booklet
and bring this with you! Here, we will evaluate whether Spravato therapy is suitable for you and work together to discuss your therapy options.
Payment Options
At Optimum TMS and Wellness Suites, we strive to make mental health care accessible to as many people as possible. In addition to cash and credit card payments, we also work with CareCredit to provide greater flexibility in obtaining your mental health treatment. We accept most private and public health insurance policies, including Medicare and Medicaid.
Reach out soon! Our team of board-certified psychiatrists, psychiatric nurse practitioners, and compassionate administration members are dedicated to providing accessible, patient-centered care and want to ensure your comfort in proceeding with any treatment.
What Is Esketamine?
Esketamine is a derivative of the drug ketamine, which is used medically as an anesthetic. More recently, research has demonstrated success in treating depression with ketamine. This drug is limited to intravenous delivery, which may not be preferable for all patients.
Esketamine demonstrates similar results in reducing depressive symptoms. Unlike ketamine, esketamine can be absorbed by the nasal mucosa, allowing it to be administered via a nasal spray (ie. Spravato). Intravenous esketamine therapy is still possible but is not offered at our clinic.
Why Esketamine for Depression
How it works:
Esketamine operates via a different neural system than typical antidepressants. It alters activity in a particular neurotransmitter system; glutamate. This results in a greater availability of glutamate in the brain and overall elevated levels of brain activity. Greater stimulation in the brain in this way can reduce regulate depressive symptoms (eg. low mood).
Benefits:
In a group of adults with treatment-resistant depression, a greater reduction in depressive symptoms was observed in those who took Spravato and an oral antidepressant (compared to a group who received a placebo in place of Spravato therapy). This outcome was observed at 4 weeks.
In a long-term study, patients who continued their Spravato treatment were less likely to experience a return of depressive symptoms, compared to patients who discontinued therapy. This was recorded at 16 weeks after Spravato therapy.
Short-term and long-term evidence:
Esketamine’s unique mechanism makes it a great option for those who have had difficulties seeing results with prior treatment. Up to 33% of people have low response rates to conventional antidepressants. Clinical trials have shown that esketamine is able to reduce depressive symptoms in most of these individuals.
Compared to conventional antidepressants, which may require weeks to take effect, Spravato therapy provides rapid relief of depressive symptoms within hours of administration.
Are There Side Effects of Spravato?
In 2019, Spravato received FDA approval as medication for treatment-resistant depression (no observed reduction in depressive symptoms after trialing at least 2 types of medication) when used in conjunction with an oral antidepressant. However like many forms of mental health treatment, there is a risk of side effects involved.
The most common side effects include:
Changes in mood (eg. happy, anxious)
Physical reactions (eg. bladder problems, changes in blood pressure, nausea)
Dissociation from thoughts and feelings
Sleepiness or lack of energy
Dizziness
If side effects occur, they generally present 40 minutes after Spravato administration and subside after approximately 2 to 4 hours. Short-term and long-term studies found that less than 7% of patients cease Spravato therapy due to the occurrence of side effects.
What to Expect
Spravato therapy involves a strict dosage and treatment schedule to ensure safe, effective delivery of esketamine for optimal results.
After your session:
- Your healthcare provider will monitor you for 2 hours after your session to confirm when you are ready to go home.
- You will be unable to drive, so you are welcome to bring a support person who can drive you home. However, only patients will be allowed in the treatment and observation room.

- You may not return to work until after a restful sleep.
Your Next Steps
If you are experiencing difficulties treating depressive symptoms and are seeking an effective, novel treatment, book a consultation with us today!
To reach out, call 614-933-4200 or visit our
contact page. When coming into your first appointment, please fill out the form at the end of our
consultation booklet and bring this with you! Here, we will evaluate whether Spravato therapy is suitable for you and work together to discuss your therapy options.
Payment Options
At Optimum TMS and Wellness Suites, we strive to make mental health care accessible to as many people as possible. In addition to cash and credit card payments, we also work with CareCredit to provide greater flexibility in obtaining your mental health treatment. We accept most private and public health insurance policies, including Medicare and Medicaid.
Reach out soon! Our team of board-certified psychiatrists, psychiatric nurse practitioners, and compassionate administration members are dedicated to providing accessible, patient-centered care and want to ensure your comfort in proceeding with any treatment.
Schedule an Appointment
Call
614-933-4200
or complete our simple online form.
Contact Us
Thank you for contacting us.
We will get back to you as soon as possible.
We will get back to you as soon as possible.
Oops, there was an error sending your message.
Please try again later.
Please try again later.
Take Control of Your Mental Health
Struggling with treatment resistant depression? Spravato could be the breakthrough treatment you need. Learn how this FDA-approved therapy can provide rapid relief and support your mental health journey.
For more information about Spravato esketamine or to schedule an appointment, call us at
614-933-4200
or
visit our contact page.
"I just finished a full course of TMS at Optimum and had a fantastic overall experience! The treatment itself worked even better than I expected - which was shocking for me, given that I have struggled with treatment resistant depression for most of my life and was in the worst depressive episode I’d had in years when I started TMS. My symptoms decreased enough to make a HUGE difference in my day to day life, and it gave me the energy and motivation to keep investing in my mental health post-TMS. The entire staff is thoughtful, funny, and super friendly, and they were always very quick to help me accommodate my changing schedule and work with my insurance..."
Poppi
Services & Resources
Frequently Asked Questions
Your Spravato Questions, Answered
Is Spravato addictive?
Spravato has a potential for dependence, so it is available only through the Spravato REMS (Risk Evaluation and Mitigation Strategy) program, ensuring safe and monitored use.
How is Spravato administered?
Spravato is self-administered as a nasal spray under the supervision of a healthcare provider at a certified treatment center.
Is Spravato covered by insurance?
Yes, coverage for Spravato may vary depending on the individual's insurance plan and the specific criteria set by the insurer.
How long does it take for Spravato to work?
Some patients notice improvement in symptoms within hours or days, while others may require several weeks of treatment to experience significant benefits.
Can Spravato be used with other medication?
Yes, Spravato is used alongside oral antidepressants as part of a comprehensive treatment plan for TRD.
How often is Spravato administered?
Treatment begins twice weekly for the first four weeks, followed by once weekly or biweekly sessions based on individual response.
Serving Ohio Since 2017
Why Choose Optimum TMS
Our team of board-certified psychiatrists, psychiatric nurse practitioners, TMS technicians, and compassionate administration members are dedicated to providing accessible, patient-centered care and want to ensure your comfort in proceeding with any treatment.
Insurance Accepted
Including Medicare
Financing Available
With CareCredit
Accelerated TMS
5 Day Relief Program
Personalized Treatment
Tailored to You
Combined Treatments
Spravato and TMS
Expert Care
Board-Certified Psychiatrist
Flexible Plans to Fit Your Budget
We’re committed to making Spravato as accessible as possible
Insurance Coverage: We work with leading providers like Aetna, Cigna, Medicare, and more, and can assist in navigating coverage criteria.
CareCredit: Finance your treatment with CareCredit, allowing for tailored payment plans.
Spravato Treatment Process
Spravato therapy involves a strict dosage and treatment schedule to ensure safe, effective delivery of esketamine for optimal results.
Consultation
Consultation with Dr. Blair: During this initial consultation, Dr. Blair will assess your mental health history, current symptoms, and treatment history to determine if Spravato is a suitable option for you.
Enrollment Forms
Completion of enrollment forms is necessary to initiate the treatment process. Dr. Blair will call in the prescription to the pharmacy, and you may receive a notification about its readiness for pickup. Please disregard this message, as the prescription will be delivered to our office before your treatment day.
Pharmacy
Medication is either billed through Metro Psychiatry, Genoa Pharmacy, or CVS Specialty. Please understand if you receive a bill from one of these companies while receiving treatment, it is correct.
Prior Authorization
Optimum TMS will handle the submission of prior authorization to your insurance
company.
Treatment Schedule
Once approved, Optimum TMS will schedule your Spravato sessions. Initially, treatment involves receiving doses twice a week for the first four weeks. The frequency may then be adjusted based on your response to treatment and Dr. Blair's recommendations.
Meet With Dr. Blair
At the end of the initial induction and optimization phase, you'll have a follow-up appointment with Dr. Blair. This allows for a review of your progress and any adjustments needed to your treatment plan.
Long-Term Management
Dr. Blair will collaborate with you to develop a long-term management plan for your depression. This may include continued Spravato treatment, along with other interventions such as psychotherapy, medication management, or lifestyle changes.
Contact Us
Call
614-933-4200
or complete our simple online form.
Contact Us
Thank you for contacting us.
We will get back to you as soon as possible.
We will get back to you as soon as possible.
Oops, there was an error sending your message.
Please try again later.
Please try again later.
For more information about Spravato esketamine or to schedule an appointment, call us at
614-933-4200
or
visit our contact page.
"I just finished a full course of TMS at Optimum and had a fantastic overall experience! The treatment itself worked even better than I expected - which was shocking for me, given that I have struggled with treatment resistant depression for most of my life and was in the worst depressive episode I’d had in years when I started TMS. My symptoms decreased enough to make a HUGE difference in my day to day life, and it gave me the energy and motivation to keep investing in my mental health post-TMS. The entire staff is thoughtful, funny, and super friendly, and they were always very quick to help me accommodate my changing schedule and work with my insurance..."
Poppi
Services & Resources
Frequently Asked Questions
Your Spravato Questions, Answered
Is Spravato addictive?
Spravato has a potential for dependence, so it is available only through the Spravato REMS (Risk Evaluation and Mitigation Strategy) program, ensuring safe and monitored use.
How is Spravato administered?
Spravato is self-administered as a nasal spray under the supervision of a healthcare provider at a certified treatment center.
Is Spravato covered by insurance?
Yes, coverage for Spravato may vary depending on the individual's insurance plan and the specific criteria set by the insurer.
How long does it take for Spravato to work?
Some patients notice improvement in symptoms within hours or days, while others may require several weeks of treatment to experience significant benefits.
Can Spravato be used with other medication?
Yes, Spravato is used alongside oral antidepressants as part of a comprehensive treatment plan for TRD.
How often is Spravato administered?
Treatment begins twice weekly for the first four weeks, followed by once weekly or biweekly sessions based on individual response.
Serving Ohio Since 2017
Why Choose Optimum TMS
Our team of board-certified psychiatrists, psychiatric nurse practitioners, TMS technicians, and compassionate administration members are dedicated to providing accessible, patient-centered care and want to ensure your comfort in proceeding with any treatment.
Insurance Accepted
Including Medicare
Financing Available
With CareCredit
Personalized Treatment
Tailored to You
Combined Treatments
Spravato and TMS
Accelerated TMS
5 Day Relief Program
Expert Care
Board-Certified Psychiatrist
Flexible Plans to Fit Your Budget
We’re committed to making Spravato as accessible as possible
Insurance Coverage: We work with leading providers like Aetna, Cigna, Medicare, and more, and can assist in navigating coverage criteria.
CareCredit: Finance your treatment with CareCredit, allowing for tailored payment plans.
Spravato Treatment Process
Spravato therapy involves a strict dosage and treatment schedule to ensure safe, effective delivery of esketamine for optimal results.
Consultation
Consultation with Dr. Blair: During this initial consultation, Dr. Blair will assess your mental health history, current symptoms, and treatment history to determine if Spravato is a suitable option for you.
Enrollment Forms
Completion of enrollment forms is necessary to initiate the treatment process. Dr. Blair will call in the prescription to the pharmacy, and you may receive a notification about its readiness for pickup. Please disregard this message, as the prescription will be delivered to our office before your treatment day.
Pharmacy
Medication is either billed through Metro Psychiatry, Genoa Pharmacy, or CVS Specialty. Please understand if you receive a bill from one of these companies while receiving treatment, it is correct.
Prior Authorization
Optimum TMS will handle the submission of prior authorization to your insurance
company.
Treatment Schedule
Once approved, Optimum TMS will schedule your Spravato sessions. Initially, treatment involves receiving doses twice a week for the first four weeks. The frequency may then be adjusted based on your response to treatment and Dr. Blair's recommendations.
Meet With Dr. Blair
At the end of the initial induction and optimization phase, you'll have a follow-up appointment with Dr. Blair. This allows for a review of your progress and any adjustments needed to your treatment plan.
Long-Term Management
Dr. Blair will collaborate with you to develop a long-term management plan for your depression. This may include continued Spravato treatment, along with other interventions such as psychotherapy, medication management, or lifestyle changes.
Contact Us
Thank you for contacting us.
We will get back to you as soon as possible.
We will get back to you as soon as possible.
Oops, there was an error sending your message.
Please try again later.
Please try again later.
For more information about Spravato esketamine or to schedule an appointment, call us at
614-933-4200
or
visit our contact page.
"I just finished a full course of TMS at Optimum and had a fantastic overall experience! The treatment itself worked even better than I expected - which was shocking for me, given that I have struggled with treatment resistant depression for most of my life and was in the worst depressive episode I’d had in years when I started TMS. My symptoms decreased enough to make a HUGE difference in my day to day life, and it gave me the energy and motivation to keep investing in my mental health post-TMS. The entire staff is thoughtful, funny, and super friendly, and they were always very quick to help me accommodate my changing schedule and work with my insurance..."
Poppi
Services & Resources
Frequently Asked Questions
Your Spravato Questions, Answered
Is Spravato addictive?
Spravato has a potential for dependence, so it is available only through the Spravato REMS (Risk Evaluation and Mitigation Strategy) program, ensuring safe and monitored use.
How is Spravato administered?
Spravato is self-administered as a nasal spray under the supervision of a healthcare provider at a certified treatment center.
Is Spravato covered by insurance?
Yes, coverage for Spravato may vary depending on the individual's insurance plan and the specific criteria set by the insurer.
How long does it take for Spravato to work?
Some patients notice improvement in symptoms within hours or days, while others may require several weeks of treatment to experience significant benefits.
Can Spravato be used with other medication?
Yes, Spravato is used alongside oral antidepressants as part of a comprehensive treatment plan for TRD.
How often is Spravato administered?
Treatment begins twice weekly for the first four weeks, followed by once weekly or biweekly sessions based on individual response.
Serving Ohio Since 2017
Why Choose Optimum TMS
Our team of board-certified psychiatrists, psychiatric nurse practitioners, TMS technicians, and compassionate administration members are dedicated to providing accessible, patient-centered care and want to ensure your comfort in proceeding with any treatment.
Insurance Accepted
Including Medicare
Financing Available
With CareCredit
Accelerated TMS
5 Day Relief Program
Personalized Treatment
Tailored to You
Combined Treatments
Spravato and TMS
Expert Care
Board-Certified Psychiatrist
Flexible Plans to Fit Your Budget
We’re committed to making Spravato as accessible as possible
Insurance Coverage: We work with leading providers like Aetna, Cigna, Medicare, and more, and can assist in navigating coverage criteria.
CareCredit: Finance your treatment with CareCredit, allowing for tailored payment plans.
Spravato Treatment Process
Spravato therapy involves a strict dosage and treatment schedule to ensure safe, effective delivery of esketamine for optimal results.
Consultation
Consultation with Dr. Blair: During this initial consultation, Dr. Blair will assess your mental health history, current symptoms, and treatment history to determine if Spravato is a suitable option for you.
Enrollment Forms
Completion of enrollment forms is necessary to initiate the treatment process. Dr. Blair will call in the prescription to the pharmacy, and you may receive a notification about its readiness for pickup. Please disregard this message, as the prescription will be delivered to our office before your treatment day.
Pharmacy
Medication is either billed through Metro Psychiatry, Genoa Pharmacy, or CVS Specialty. Please understand if you receive a bill from one of these companies while receiving treatment, it is correct.
Prior Authorization
Optimum TMS will handle the submission of prior authorization to your insurance
company.
Treatment Schedule
Once approved, Optimum TMS will schedule your Spravato sessions. Initially, treatment involves receiving doses twice a week for the first four weeks. The frequency may then be adjusted based on your response to treatment and Dr. Blair's recommendations.
Meet With Dr. Blair
At the end of the initial induction and optimization phase, you'll have a follow-up appointment with Dr. Blair. This allows for a review of your progress and any adjustments needed to your treatment plan.
Long-Term Management
Dr. Blair will collaborate with you to develop a long-term management plan for your depression. This may include continued Spravato treatment, along with other interventions such as psychotherapy, medication management, or lifestyle changes.
Contact Us
Call
614-933-4200
or complete our simple online form.
Contact Us
Thank you for contacting us.
We will get back to you as soon as possible.
We will get back to you as soon as possible.
Oops, there was an error sending your message.
Please try again later.
Please try again later.
